Chromatin Loop Regulation by TLK2 Emerges as Key Mechanism in Cancer Stem Cell Plasticity
Scientists have identified TLK2 as a critical regulator of chromatin loop formation influencing cancer stem cell plasticity. The findings suggest targeting chromatin architecture could provide new avenues for combating treatment-resistant cancers. This discovery opens potential pathways for disrupting cancer stemness mechanisms.
Breakthrough in Cancer Stem Cell Research
Researchers have uncovered a previously unknown mechanism controlling cancer stem cell plasticity through chromatin loop regulation, according to a recent study published in Nature Communications. The report states that the protein TLK2 plays a crucial role in forming CTCF-cohesin hubs that maintain chromatin architecture, potentially influencing how cancer cells adapt and resist treatments.