ResearchScienceTechnology

Human DNA Polymerase ι Bypasses Cancer-Causing DNA Damage Through Alternative Base Pairing

Scientists have uncovered how human DNA polymerase ι successfully replicates past a carcinogenic DNA lesion that typically blocks other repair mechanisms. The enzyme employs an alternative base pairing method to bypass damage caused by environmental toxins and cellular stress, according to new structural biology findings.

Novel DNA Repair Mechanism Uncovered

Researchers have identified how specialized enzymes in human cells can replicate past carcinogenic DNA damage that would normally block replication, according to reports published in Nature Structural & Molecular Biology. The study reveals that human DNA polymerase ι (Polι) employs an alternative base pairing strategy to bypass the 1,N6-ethenodeoxyadenosine (adduct) lesion, a known cancer-causing DNA modification.

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Gartner Forecasts AI-Driven Enterprise Transformation by 2026

Analysts suggest that by 2026, AI will no longer be optional but foundational to enterprise operations. The report emphasizes the need for secure, scalable systems and proactive risk management in a rapidly evolving digital landscape.

AI Integration Becomes Core to Enterprise Strategy

According to reports from Gartner’s recent Symposium, the strategic technology trends for 2026 indicate a significant shift in how businesses approach artificial intelligence and digital infrastructure. Sources indicate that disruption is accelerating, making innovation a central focus rather than a supplementary project. Technology leaders are urged to align their digital strategies with business goals and scale innovations securely to stay competitive.